Nikola Mirotic netted 28 points as the Bulls blasted the Pistons 117-95. Jimmy Butler had 16 points and 12 assists for Chicago, which moved into a tie with Detroit for ninth in the East.
Bulls center Robin Lopez served a one-game suspension for his role in Tuesday's scuffle with Toronto's Serge Ibaka.
Marcus Morris and Tobias Harris scored 14 points apiece for Detroit, which came up short for the fifth time in six games.
The Bulls return to the Unioted Center on Friday night against Philadelphia.
